While Medvedev said he was "lucky" he felt better and could continue his match to advance, Spain's Paula Badosa gave up.
Naomi Osaka ended Victoria Azarenka's dream run to claim her second US Open title in three years with a 1-6, 6-3, 6-3 comeback win on Saturday which cemented her status as the sport's leading light both on and off the court.
Germany's second seeded Angelique Kerber beat Czech Karolina Pliskova 6-3, 4-6, 6-4 to win the US Open final on Saturday, and collect her second Grand Slam title of the year.
Images from Day 1 of the 2022 US Open at the USTA Billie Jean King National Tennis Center, in Flushing Meadows, New York, on Monday.
'It's a tough loss, but it was obviously a great experience' 'I'd love to build on these two weeks'
Still shaking off the rust from a 15-month doping ban and a string of nagging injuries, the 30-year-old Sharapova needed all her skill, determination and two hours and 44 minutes to snatch victory in front of a packed Arthur Ashe stadium.
With the physical demands of modern-day tennis taking its toll the tournament will start without four of the top 11 in the ATP rankings including defending champion Stan Wawrinka who ended his season early with a knee injury.
Runner-up Pliskova will move into the top-10 of the world rankings for the first time in her career
Sloane Stephens will be defending her title at the U.S. Open but all eyes will be on Serena Williams over the coming two weeks as the six-times champion attempts to win her first Grand Slam title since becoming a mother.
Images from Day 2 at the US Open played at Flushing Meadows in New York on Tuesday
With the American men experiencing their longest US Open title drought in the Open era, Venus Williams led the American charge into round two on Monday with a 6-3, 3-6, 6-2 win over Viktoria Kuzmova of Slovakia.
The World No 1 beat Japan's Kei Nishikori for his 63rd career title
The dinner Jill Biden and her husband US President Joe Biden hosted for Indian prime minister Narendra Modi, June 22, at the White House brought together, Indians and Americans from so many firmaments.
A summary of Saturday's action at the US Open.
A summary of Novak Djokovic's rise in the tennis circuit in photos.
Unlike the women's US Open final there was no centre court retirement announcement on Sunday with Roger Federer putting aside the disappointment of losing to Novak Djokovic in the men's final to tell fans he will be back.
'I don't know. It's tough to explain my emotion right now. Maybe tomorrow morning I can tell you something, but now it's amazing'
Federer has been brandishing an aggressive style of play, forcing the action and rushing in to half-volley weak second serves to forge an advantage.
'There are some challenges and combining parenting at home and teaching the kids at home and still going to practice and things like that, so it was challenging but at the same time you get through that together.'
Defending champion Serena Williams reached the semi-finals of the Western & Southern tournament in Cincinnati but not before having her mettle tested in a 3-6, 6-4, 6-2 win over sixth-seeded Serb Ana Ivanovic on Friday.
Indian Wells organisers said on Tuesday that world number two Novak Djokovic had been placed in the tournament's draw but it was unclear if the Serbian would be permitted to enter the United States.
Tennis sensation Maria Sharapova ensured all eyes would be on her as she attended the Vanity Fair Oscar Party on Sunday night in a glamorous silver gown.
The 35-year-old Swiss, showing no sign of losing his edge, improved to 19-1 this year, winning the Australian Open in five sets over Nadal, and BNP Paribas Open in straight sets over fellow Swiss Stan Wawrinka.
The women's draw at the US Open has been in news for the upsets it created. Almost everyday one or some days even two of the top seeds feel to unknown players.
World No 1 Novak Djokovic will face Britain's Andy Murray in the final of the Miami Open for a third time on Sunday after the pair triumphed in their semi-finals.
Azarenka punished her Russian opponent's weak serve to wrap up the final in 80 minutes in relentless humidity under a searing sun in the early afternoon encounter on the Key Biscayne hardcourt.
Here is a list of US Open women's singles champions since the open era began in 1968:
Since claiming the title in her US Open main draw debut, Andreescu has had a trophy photoshoot atop Rockefeller Center and appeared on several US morning shows in New York to discuss her breakthrough win.
Sports stars in Rajasthan and Telangana stepped out to cast their vote on Friday.
Tennis stars Serena Williams, Roger Federer and Maria Sharapova came in their finest best at the 88th Annual Academy Awards at Hollywood & Highland Center in Hollywood, California on Sunday.
But for the 23-year-old Bouchard, a former world number five who has slumped to 56th in the rankings, it was another blow after her first-round exit in Indian Wells.
Andy Murray said on Thursday the noise created by the US Open's new retractable roof over Arthur Ashe Stadium is a distraction to players and makes it difficult to react to opponents' shots.
A summary of Friday's tennis action from around the world.
IMAGES from the matches played at the Miami Masters on Sunday
A six-time champion at Flushing Meadows, Williams was once money in the bank when it came to the US Open
Olympics-related cases rose by 19, organisers said, bringing the total number of disclosed cases to 106.
The winners of the season's first three grand slams Novak Djokovic, Andy Murray and Rafa Nadal put on a masterclass at the Western and Southern Open on Wednesday, strolling into the third round with straight sets wins.
Naomi Osaka continued her stunning run of form with a 6-3, 6-2 victory over 23-times Grand Slam champion Serena Williams in the first round of the Miami Open on Wednesday, the latest big win for the 20-year-old Japanese player.
Serena Williams has been vulnerable this Grand Slam season but unbeaten in the year's first three major championships.
A summary of Sunday's action at the US Open.
